Metabolic Profile of Alzheimer’s Disease: Is 10-Hydroxy-2-decenoic Acid a Pertinent Metabolic Adjuster?

Alzheimer’s disease (AD) represents a significant public health concern in modern society. Metabolic syndrome (MetS), which includes diabetes mellitus (DM) and obesity, modifiable risk factor for AD. MetS AD are interconnected through various mechanisms, such as mitochondrial dysfunction, oxidative stress, insulin resistance (IR), vascular impairment, inflammation, endoplasmic reticulum (ER) stress. Therefore, it is necessary to seek multi-targeted safer approach intervention. Thus, 10-hydroxy-2-decenoic acid (10-HDA), unique hydroxy fatty royal jelly, has shown promising anti-neuroinflammatory, blood–brain barrier (BBB)-preserving, neurogenesis-promoting properties. In this paper, we provide summary of the relationship between AD, together with an introduction 10-HDA potential intervention nutrient. addition, molecular docking performed explore metabolic tuning properties associated macromolecules GLP-1R, PPARs, GSK-3, TREM2. conclusion, there close MetS, shows beneficial nutritional both MetS.